Introducing a scoring system based on HER2/neu, p53, and mammography

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Introducing a scoring system based on HER2/neu, p53, and mammography results for correlation of Nottingham score in invasive ductal carcinoma

Sub-category

Other: Biology of Risk and Prevention

Category:

Biology of Risk and Prevention

Meeting:

2007 Breast Cancer Symposium

Session Type and Session Title:

General Poster Session A

Abstract No:

14

Author(s):

M. Mokri, S. Shariat Torbaghan, M. Guity, M. Shakiba, M. Atri

Abstract:

Introduction: To investigate the correlation of the results of a scoring system comprised of mammogram, p53, and HER2/neu with the Nottingham score tumor grade in invasive ductal carcinoma. Methods: 318 cases of pathology proven invasive ductal carcinoma of a day hospital were included. According to BIRADS system, the mammography results received the scores of 1 (benign: groups of I and II in BIRADS ), 2 (suspicious: group III in BIRADS) and 3 (malignant: groups of IV and V in BIRADS). p53 and HER2/neu presence were assessed by immunohistochemical studies, and the results were scored equal to 1 (negative results) and 2 (positive results).Tumor grade was assessed by Nottingham score grading system and the grades of 7-9 were considered as high-grade and the others were considered as low-grade tumors. The final score of each patient was calculated by adding scores of all three studies (p53, HER2, mammography) which ranged between 3 and 7. Results: The mean age was 50.2±9.9 years. 287 cases (60.3%) had suspicious and 29 (9.1%) had malignant mammograms. Positive p53 was seen in 133 (41.8%), positive HER2/neu in 135 (42.5%), and high-grade tumor in 119 (37.4%) patients. The number of patients with scores of 4, 5, 6, and 7 were 98 (28.2%), 145 (41.7%), 68 (19.5%), and 7 (2%), respectively. Placing score of 4 in one group and 5-7 in another, the sensitivity and negative predictive value of the system for high-grade tumors reached 77.3% and 72.4%, respectively. By placing scores 4, 5 in one group and scores 6, 7 in another, the specificity of the system reached to 80.9%. Conclusions: The results of mammography, p53, and HER2/neu have a good correlation with Nottingham score.

 

http://www.asco.org/ASCOv2/images/orange_arrow.gif  Associated Presentation(s):

    

1. Introducing a scoring system based on Her2/neu, p53 and mammography results for correlation of Nottingham score in invasive ductal carcinoma.

Meeting: 2007 Breast Cancer Symposium
Presenter: Mehrdad Mokri http://www.asco.org/ASCOv2/images/General/clear.gif
Session: General Poster Session A (General Poster Session)

 

http://www.asco.org/ASCOv2/images/orange_arrow.gif  Other Abstracts in this Sub-Category:

    

1. Effect of treatment with adjuvant anastrozole on cumulative gene methylation in the contralateral breast of women at increased risk for a second breast cancer

Meeting: 2007 Breast Cancer Symposium   Abstract No: 1   First Author: T. M. Prowell http://www.asco.org/ASCOv2/images/General/clear.gif
Category: Biology of Risk and Prevention - Other: Biology of Risk and Prevention

    

2. Ductal carcinoma in situ (DCIS) and the emergence of diversity during breast cancer evolution

Meeting: 2007 Breast Cancer Symposium   Abstract No: 2   First Author: D. C. Allred http://www.asco.org/ASCOv2/images/General/clear.gif
Category: Biology of Risk and Prevention - Other: Biology of Risk and Prevention

    

3. All LCIS is not created equal

Meeting: 2007 Breast Cancer Symposium   Abstract No: 3   First Author: M. Morrogh http://www.asco.org/ASCOv2/images/General/clear.gif
Category: Biology of Risk and Prevention - Other: Biology of Risk and Prevention

    

More...

 

http://www.asco.org/ASCOv2/images/orange_arrow.gif  Abstracts by M. Mokri:

    

1. Tumor characteristics and patient outcomes in ductal compared with lobular carcinoma.

Meeting: 2010 ASCO Annual Meeting   Abstract No: 10614   First Author: S. Nour http://www.asco.org/ASCOv2/images/General/clear.gif
Category: Tumor Biology - Prognostic Factors

    

2. What is the correlation between Nottingham score and receptor status in malignant breast cancer

Meeting: 2008 Molecular Markers   Abstract No: 86   First Author: M. Mokri http://www.asco.org/ASCOv2/images/General/clear.gif
Category: Proteomics/Immunohistochemistry

    

3. Current demographics and outcomes of resectable breast cancer in Iranian women

Meeting: 2008 Breast Cancer Symposium   Abstract No: 108   First Author: M. Mokri http://www.asco.org/ASCOv2/images/General/clear.gif
Category: Epidemiology, Biology, and Health Services Research - Other: Epidemiology, Biology, and Health Services Research

    

More... http://www.asco.org/ASCOv2/images/General/clear.gif

 

http://www.asco.org/ASCOv2/images/orange_arrow.gif  Presentations by M. Mokri:

    

1. What is the correlation between Nottingham score and receptor status in malignant breast cancer

Meeting: 2008 Molecular Markers
Presenter: Mehrdad Mokri, MD http://www.asco.org/ASCOv2/images/General/clear.gif
Session: General Poster Session B (General Poster Session)

    

2. Current demographics and outcomes of resectable breast cancer in Iranian women

Meeting: 2008 Breast Cancer Symposium
Presenter: Mehrdad Mokri, MD http://www.asco.org/ASCOv2/images/General/clear.gif
Session: General Poster Session A (General Poster Session)

    

3. Introducing a scoring system based on Her2/neu, p53 and mammography results for correlation of Nottingham score in invasive ductal carcinoma.

Meeting: 2007 Breast Cancer Symposium
Presenter: Mehrdad Mokri http://www.asco.org/ASCOv2/images/General/clear.gif
Session: General Poster Session A (General Poster Session)

 

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