Introducing a scoring system based on HER2/neu, p53, and mammography results for correlation of Nottingham score in invasive ductal carcinoma
Sub-category
Other: Biology of Risk and Prevention
Category:
Biology of Risk and Prevention
Meeting:
Session Type and Session Title:
General Poster Session A
Abstract No:
14
Author(s):
M. Mokri, S. Shariat Torbaghan, M. Guity, M. Shakiba, M. Atri
Abstract:
Introduction: To investigate the correlation of the results of a scoring system comprised of mammogram, p53, and HER2/neu with the Nottingham score tumor grade in invasive ductal carcinoma. Methods: 318 cases of pathology proven invasive ductal carcinoma of a day hospital were included. According to BIRADS system, the mammography results received the scores of 1 (benign: groups of I and II in BIRADS ), 2 (suspicious: group III in BIRADS) and 3 (malignant: groups of IV and V in BIRADS). p53 and HER2/neu presence were assessed by immunohistochemical studies, and the results were scored equal to 1 (negative results) and 2 (positive results).Tumor grade was assessed by Nottingham score grading system and the grades of 7-9 were considered as high-grade and the others were considered as low-grade tumors. The final score of each patient was calculated by adding scores of all three studies (p53, HER2, mammography) which ranged between 3 and 7. Results: The mean age was 50.2±9.9 years. 287 cases (60.3%) had suspicious and 29 (9.1%) had malignant mammograms. Positive p53 was seen in 133 (41.8%), positive HER2/neu in 135 (42.5%), and high-grade tumor in 119 (37.4%) patients. The number of patients with scores of 4, 5, 6, and 7 were 98 (28.2%), 145 (41.7%), 68 (19.5%), and 7 (2%), respectively. Placing score of 4 in one group and 5-7 in another, the sensitivity and negative predictive value of the system for high-grade tumors reached 77.3% and 72.4%, respectively. By placing scores 4, 5 in one group and scores 6, 7 in another, the specificity of the system reached to 80.9%. Conclusions: The results of mammography, p53, and HER2/neu have a good correlation with Nottingham score.
Associated Presentation(s):
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1. Introducing a scoring system based on Her2/neu, p53 and mammography results for correlation of Nottingham score in invasive ductal carcinoma.
Meeting: 2007 Breast Cancer Symposium |
Other Abstracts in this Sub-Category:
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Meeting: 2007 Breast Cancer Symposium Abstract No: 1 First Author: T. M. Prowell |
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2. Ductal carcinoma in situ (DCIS) and the emergence of diversity during breast cancer evolution
Meeting: 2007 Breast Cancer Symposium Abstract No: 2 First Author: D. C. Allred |
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3. All LCIS is not created equal
Meeting: 2007 Breast Cancer Symposium Abstract No: 3 First Author: M. Morrogh |
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Abstracts by M. Mokri:
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1. Tumor characteristics and patient outcomes in ductal compared with lobular carcinoma.
Meeting: 2010 ASCO Annual Meeting Abstract No: 10614 First Author: S. Nour |
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2. What is the correlation between Nottingham score and receptor status in malignant breast cancer
Meeting: 2008 Molecular Markers Abstract No: 86 First Author: M. Mokri |
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3. Current demographics and outcomes of resectable breast cancer in Iranian women
Meeting: 2008 Breast Cancer Symposium Abstract No: 108 First Author: M. Mokri |
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Presentations by M. Mokri:
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1. What is the correlation between Nottingham score and receptor status in malignant breast cancer
Meeting: 2008 Molecular Markers |
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2. Current demographics and outcomes of resectable breast cancer in Iranian women
Meeting: 2008 Breast Cancer Symposium |
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3. Introducing a scoring system based on Her2/neu, p53 and mammography results for correlation of Nottingham score in invasive ductal carcinoma.
Meeting: 2007 Breast Cancer Symposium |